The extracellular RNA and drug resistance in cancer: a narrative review

Background and Objective: Extracellular RNA (exRNA) is an evolving concept. In one hand, more endogenous types are detected in various biofluids or found local extracellular space. These exRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular (circRNAs), piwi-interacting (piRNAs), transfer (tRNAs) protein-coding messenger (mRNAs). ExRNA profilings associated with many physiopathological conditions, including drug resistance cancer. Endogenous also significantly involved the molecular mechanisms of cancer resistance. other exRNA expanded to exogenous therapeutics which started headline recent years approval several RNA-based drugs. This review discusses current knowledge function resistance, their value as biomarkers, significant roles modulating usage relieve